NKFI gyorsítósáv 2021

The implementation of the Gyorsítósáv Projekt has started

Minimally invasive endovascular interventions play an increasing role in the modern health care systems because they reduce the risk and significantly shorten the hospitalization of patients. These techniques are widely used in the treatment of cardiovascular disorders (the leading cause of death in western societies), oncological disorders, and other tissue proliferative states (like myoma or prostate hypertrophy). During these interventions, angiographic examinations are needed for the diagnosis of pathological states and checking the efficacy of treatment. Kinepict Health Ltd has developed a new image processing technology, Digital Variance Angiography (DVA), that outperforms the currently used Digital Subtraction Angiography (DSA) because it provides significantly better signal-to-noise ratios and improved image quality. This quality reserve allows a very substantial reduction of radiation dose (at least by 70%) and contrast agent volume (at least by 50%), thereby the safety of interventions is increasing whereas the costs are reduced. The proprietary DVA technology was implemented in an angiography platform-independent software, the Kinepict Medical Imaging Tool (KMIT), that received CE mark and FD -approval. Thus, the product can be freely marketed in the EU and the US. The aim of the present project is to develop a new DVA-based module (stand-alone or combined with the existing KMIT version), which is able to quantitatively analyze the hemodynamic parameters, thereby provides real-time decision support for the interventional physician in the operating room. There are two major types of endovascular intervention. The restorative interventions aim to resolve the stenosis and occlusions of sclerotic arteries in order to restore the circulation and blood supply of tissues, whereas the embolization procedures reduce or suspend the blood supply of pathological areas (tumors, hyperplastic tissues) in order to reduce or eliminate the pathology. In both types, there is a change in the blood flow (increase or decrease) compared to the pre-interventional states, and the extent of this change defines the efficacy of the intervention. In many cases, the outcome can be judged only retrospectively after the operation, and a repeated session might be necessary to achieve optimal results. By the use of hemodynamic parameters, the physicians might decide in real-time at the operating table, whether the intervention was successful or not, and can continue the procedure in one session until the desired result is reached. Thus, the repeated intervention might be avoided, resulting in a substantial reduction of health care costs and improved quality of life for the patients. 2020-1.1.5-GYORSÍTÓSÁV-2021-00018 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the 2020-1.1.5-GYORSÍTÓSÁV funding scheme.  

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